Sequestration — Process Challenge

Food-Grade Chelating Agents for Metal-Catalyzed Oxidation (EDTA, DTPA, Gluconate)

Trace iron and copper catalyze lipid and ascorbate oxidation, driving rancidity, color loss and metallic notes; need chelants to lock up the metal
Updated Jun 2026
Solution Approach

RawSource supplies the base chemicals that go into these programs. We can help with product selection, grade matching, and sourcing from multiple origins for supply security.

Typical Formulation Workflow
1
Process & Compliance Review
Map the application and contact points, and confirm food-grade and regulatory status (FCC/USP, Kosher/Halal, allergen) for every input.
2
Ingredient & Grade Selection
Select the right grade of acidulant, preservative, emulsifier, stabilizer, or processing aid for the formulation, label, and sensory targets.
3
Bench Trial & Dosing
Validate use level and performance in a bench or pilot batch, and specify packaging and lot traceability suited to food-safety requirements.
4
Quality & Shelf-Life Validation
Verify finished-product quality, microbial stability, and shelf life, and lock the spec with a CoA and document control for audits.
Recommended Chemistries (7)
Disodium EDTA (Food Grade)
CAS 139-33-3
Specialty Additives
Chelation / Sequestration
Chelates trace iron and copper that catalyze oxidation, protecting color, flavor and ascorbate in dressings, mayo and canned goods
Physical Description: White odorless solid; White odorless crystals   Appearance: White crystalline powder   Melting Point: MP: 242 °C /EDTA disodium dihydrate/
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Tetrasodium EDTA (EDTA Na4)
CAS 64-02-8
Amines & Amides
Chelation / Sequestration
Tetrasodium EDTA gives stronger metal sequestration at higher pH
Melting Point: 300 °C (decomposes)   Density: 6.9 lb/gal /Apparent density/   Solubility: Slightly soluble in ethanol
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DTPA (Diethylenetriaminepentaacetic Acid)
CAS 67-43-6
Amines & Amides
Chelation / Sequestration
Higher-denticity chelant holds iron tightly across a wide pH range for oxidation control
Physical Description: White to off-white solid   Boiling Point: Decomposes   Melting Point: 219-220 ºC
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Sodium Gluconate (Food Grade)
CAS 527-07-1
Esters
Chelation / Sequestration
Alkali-stable sequestrant for calcium and iron that also prevents scale in CIP cleaning
Melting Point: 170-175 °C   Boiling Point: No boiling point at normal pressure; decomposes…   Density: 1.8 g/cm3
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Citric Acid
CAS 77-92-9
Acids & Salts
Chelation / Sequestration
Anhydrous citric acid, CAS verified. Canonical food-grade antioxidant synergist / metal chelator; its tricarboxylate deactivates pro-oxidant trace Fe/Cu in edible oils, fried snacks and beverages, directly stopping metal-catalyzed rancidity and metallic notes. Exact-use fit.
Melting Point: 153 °C (anhydrous)   Boiling Point: Decomposes   Density: 1.54 at 20 °C
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Tetrasodium Pyrophosphate
CAS 7722-88-5
Acids & Salts
Chelation / Sequestration
Anhydrous TSPP, CAS verified. Strong food-grade polyphosphate sequestrant of di/trivalent metals; ties up trace iron and copper to suppress metal-catalyzed lipid oxidation and color loss in aqueous food/beverage systems. Genuine fit for this exact problem.
Melting Point: 988 °C   Boiling Point: Decomposes   Density: 2.45
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Potassium Citrate FG USP/FCC
CAS 6100-05-6
Chelation / Sequestration
Tripotassium citrate monohydrate (E332ii), CAS verified. Citrate sequestrant of pro-oxidant Fe/Cu that works near-neutral pH where added acidity is undesirable; same chelant/antioxidant-synergist tier as the incumbent gluconate. Genuine fit and the standard USP/FCC commercial article of the two proposed citrate salts.
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