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Specialty Additives Available — Bulk Only

Silymarin (Milk Thistle Extract)

CAS 65666-07-1 · Formula C25H22O10 · MW 482.4 g/mol

A milk-thistle flavonolignan concentrate supplied as an antioxidant active for cosmetic and personal-care formulating. It is supplied as a botanical extract raw material and is used as an antioxidant and skin-conditioning ingredient in cosmetic formulations.

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HS Code
1302.19
At a Glance
Material Family
Specialty Additives
Record Type
Pure compound
Primary Role
Conditioning
Functional Roles
Conditioning
Industries Served
Beauty & Personal Care
Applications & Use Cases
  • ▸ Cosmetic antioxidant: Antioxidant active for skin-care and personal-care formulations.
  • ▸ Skin conditioning: Skin-conditioning botanical ingredient.
  • ▸ Botanical raw material: Standardized milk-thistle extract for formulation use.
Physical Properties
Melting Point
167 °C
Safety & Handling
Full SDS available on request

A grade-specific Safety Data Sheet (SDS) — with the complete hazard classification, handling precautions, and transport information — is supplied with every shipment and available on request. Confirm all safety and regulatory details against the SDS for your specific grade.

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HS / Tariff Classification
Harmonized System (HS) Code — 6-digit international heading
1302 . 19
Chapter 13
Chemical product (see national tariff schedule for the full classification)
Heading 13.02
Internationally harmonized (WCO HS)
Subheading 1302.19
6-digit international code — national tariff line adds further digits
Chemical Identity
CAS Number
65666-07-1
Molecular Formula
C25H22O10
Molecular Weight
482.4 g/mol
IUPAC Name
3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
PubChem CID
5213
InChI Key
SEBFKMXJBCUCAI-UHFFFAOYSA-N
Synonyms & Trade Names
SILYMARIN Silimarin Silybin Flavobin Spofa Silymarin (>80%) Silibin Apihepar SR-01000000093 Silybin;Silibinin A;Silymarin I Laragon Silmyarin
Full Description

Silymarin (CAS 65666-07-1) is a flavonolignan complex extracted from the seeds of milk thistle (Silybum marianum), comprising silybin and related isomers. It is supplied as a botanical extract raw material and is used as an antioxidant and skin-conditioning ingredient in cosmetic formulations.

Frequently Asked Questions

What is silymarin?

Silymarin (CAS 65666-07-1, C25H22O10) is a flavonolignan complex extracted from the seeds of milk thistle (Silybum marianum), comprising silybin and related isomers. RawSource supplies it as a standardized botanical extract raw material.

What is silymarin used for in formulation?

As a cosmetic raw material it is used as an antioxidant active and skin-conditioning botanical ingredient in skin-care and personal-care formulations. It is supplied as a standardized milk-thistle extract for formulation use.

What is silymarin made from?

It is extracted from the seeds of milk thistle (Silybum marianum), a flowering plant. The extract is a complex of flavonolignans, principally silybin (silibinin) and related isomers.

Is silymarin water soluble?

Silymarin flavonolignans have limited water solubility and are more soluble in polar organic solvents such as alcohols. Confirm solubility and recommended incorporation method against the product technical data before formulating.

How is silymarin supplied and quoted in bulk?

It is supplied as a standardized botanical extract (powder) under HS 1302.19, vegetable saps and extracts. RawSource quotes by volume and current market; request a bulk quote with your target quantity and standardization. A CoA and SDS are provided.

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Disclaimer. Information on this page — including properties, identifiers, hazard, transport (DOT/UN) and tariff (HS) classifications, and applications — is provided for general reference and is compiled from authoritative public sources (e.g. PubChem/ECHA, 49 CFR 172.101, the Harmonized Tariff Schedule). Values are typical and are not a guaranteed specification; the Certificate of Analysis (CoA) for the lot purchased governs. Products are sold for industrial and professional use only. Nothing here is a medical, health, or efficacy claim or advice. Always consult the current Safety Data Sheet (SDS) before handling, storage, transport or disposal, and confirm regulatory status, classification and suitability for your application and jurisdiction. Hazard, transport and tariff classifications must be verified for your specific shipment. RawSource makes no warranty, express or implied, and assumes no liability for use of this information. Trademarks. Third-party trademarks and brand names are the property of their respective owners; any reference is nominative — used only to identify a comparable product — and does not imply affiliation with, sponsorship by, or endorsement by the trademark owner.
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