- ▸ Fluorinated aniline building block for fluoroquinolone and other pharmaceutical actives (Pharmaceuticals)
- ▸ Intermediate for agrochemical and specialty chemical synthesis (Agriculture, Industrial Manufacturing)
A grade-specific Safety Data Sheet (SDS) — with the complete hazard classification, handling precautions, and transport information — is supplied with every shipment and available on request. Confirm all safety and regulatory details against the SDS for your specific grade.
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2,6-Difluoroaniline is a fluoro-aniline synthesis intermediate — a building block used in the manufacture of fluoroquinolone pharmaceutical and agrochemical intermediates. Identity: CAS 5509-65-9.
What it is
2,6-Difluoroaniline (CAS 5509-65-9, C6H5F2N) is a fluoro-aniline sold as a synthesis intermediate — a defined building block that downstream manufacturers convert into finished products.
Role in synthesis
As an aromatic amine, it can be diazotized and coupled, acylated, or condensed, while the ring substituents tune reactivity and direct further substitution. The substitution pattern (isomer) is part of the identity — confirm the CAS to be sure the isomer matches your route, because position isomers react differently and lead to different products.
What it is used to make
It is a building block toward fluoroquinolone pharmaceutical and agrochemical intermediates. RawSource supplies the intermediate; the downstream synthesis, product registration and any application or efficacy are the responsibility of the manufacturer that uses it.
Forms, grades and handling
Supplied to a defined assay with a Certificate of Analysis (CoA) per lot; define the assay and key impurity limits your route needs. Several halo-aromatic intermediates are hazardous and some are regulated — confirm regulatory status and handling for your jurisdiction, and always consult the current Safety Data Sheet (SDS). Typical values are not a guaranteed specification; the CoA governs.
Bulk and custom-quantity supply
RawSource sources 2,6-Difluoroaniline direct from producers in bulk and custom quantities, with CoA, TDS and SDS per lot. Tell us the assay and impurity limits and your sample/pilot/production quantity, and we will quote it and confirm supply continuity. See the full range in the intermediates guide.
Typical Properties
Typical reference values, not a specification; the Certificate of Analysis (CoA) for the lot governs.
| Property | Typical Value |
|---|---|
| Type | Fluoro-aniline |
| End-use class | Pharma & agrochemical intermediates |
| CAS Number | 5509-65-9 |
| Molecular Formula | C6H5F2N |
| Molecular Weight | 129.11 g/mol |
| Handling | Refer to the current SDS |
Regulatory & registration requirements
- TSCA (US):
- REACH (EU): Not determined from public registry
- EC number: 226-853-0
TSCA Inventory flag PMN: a commenced PMN (premanufacture notice) substance (EPA flag legend).
Source: EPA TSCA Inventory (July 2025 release) · ECHA CHEM — retrieved 2026-07-12
Frequently Asked Questions
What is 2,6-difluoroaniline used for?
2,6-Difluoroaniline (CAS 5509-65-9) is a fluorinated aromatic amine intermediate for pharmaceutical (e.g. fluoroquinolone-type) and agrochemical synthesis.
Can RawSource supply 2,6-difluoroaniline in bulk or custom quantities?
Yes — RawSource supplies 2,6-difluoroaniline in bulk and custom (sample/pilot/production) quantities with CoA, TDS and SDS per lot. Tell us the assay, impurity limits and quantity, and we will quote it and confirm supply.
What is the REACH and TSCA regulatory status of 2,6-Difluoroaniline?
2,6-Difluoroaniline (CAS 5509-65-9) is listed as Active on the U.S. EPA TSCA Inventory; its REACH registration status is not determined from the public ECHA registry.