TROMETHAMINE- ▸ Laboratory buffers: Biological/laboratory buffer reagent
- ▸ Cosmetics: pH-buffering ingredient in personal-care formulations
- ▸ pH regulation: Alkaline buffering agent
- ▸ Leather processing: Processing aid in tanning
- ▸ Textiles: Auxiliary in textile finishing
A grade-specific Safety Data Sheet (SDS) — with the complete hazard classification, handling precautions, and transport information — is supplied with every shipment and available on request. Confirm all safety and regulatory details against the SDS for your specific grade.
Request SDS →Tromethamine (CAS 77-86-1), also known as tris(hydroxymethyl)aminomethane or Tris, is a primary amino-alcohol. In industrial and laboratory use it functions as a buffering and pH-regulating agent, including as a biological buffer and a buffering ingredient in cosmetic formulations. It is also documented in leather tanning and textile processing.
Regulatory & registration requirements
- TSCA (US):
- REACH (EU):
- EC number: 201-064-4
Source: EPA TSCA Inventory (July 2025 release) · ECHA CHEM — retrieved 2026-07-12
Frequently Asked Questions
What is another name for tromethamine?
Tromethamine (CAS 77-86-1) is also known as tris(hydroxymethyl)aminomethane, or simply Tris. It is a primary amino-alcohol with formula C4H11NO3 and is supplied here to USP-NF compendial specifications.
What does USP NF stand for?
USP-NF refers to the United States Pharmacopeia and the National Formulary, the compendia that set quality standards for substances. A USP-NF designation on tromethamine indicates the material is tested and labeled to the corresponding compendial monograph; confirm the specific monograph and lot CoA when ordering.
What is tromethamine used for in industrial and laboratory applications?
As an industrial and laboratory chemical, tromethamine functions as a buffering and pH-regulating agent. Documented uses include biological/laboratory buffers (Tris buffer), an alkaline buffering ingredient in cosmetic formulations, and processing aids in leather tanning and textile finishing.
What is the chemical formula and CAS number of tromethamine?
The molecular formula is C4H11NO3, CAS 77-86-1, molecular weight approximately 121.1 g/mol. It is the same compound referred to as Tris or THAM in buffer chemistry.
How is tromethamine USP-NF supplied in bulk?
It is typically supplied as a crystalline solid in bags or drums to USP-NF specification. Request a bulk quote from RawSource for current packaging, lead time, and the corresponding CoA and SDS documentation.
What is the REACH and TSCA regulatory status of Tromethamine (Tris)?
Tromethamine (Tris) (CAS 77-86-1) is subject to U.S. TSCA Inventory requirements; supplying it into the EU requires valid REACH registration ((EC) No 1907/2006). RawSource cannot verify a third-party supplier's registrations — buyers should require documented TSCA and REACH compliance for their jurisdiction and volume (EC 201-064-4).