- ▸ Polymer solvent: Dissolves PVC and other high polymers and resins.
- ▸ Coatings and adhesives: Solvent in inks, lacquers, adhesives, and topcoats.
- ▸ Reaction medium: Solvent for Grignard and metal-hydride reactions.
- ▸ Chemical intermediate: Feedstock in organic synthesis.
A grade-specific Safety Data Sheet (SDS) — with the complete hazard classification, handling precautions, and transport information — is supplied with every shipment and available on request. Confirm all safety and regulatory details against the SDS for your specific grade.
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Transport classification per the UN Model Regulations / 49 CFR 172.101 Hazardous Materials Table. Confirm against the grade-specific SDS (Section 14) before shipping.
⚠ WARNING: This product can expose you to Tetrahydrofuran, which is known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Tetrahydrofuran (CAS 109-99-9) is a cyclic ether (C4H8O) and a strong aprotic solvent. it is used as a solvent for high polymers (especially PVC), in printing inks, adhesives, lacquers, and coatings, as a reaction medium for Grignard and metal-hydride reactions, and as a chemical intermediate.
Regulatory & registration requirements
- TSCA (US):
- REACH (EU):
- EC number: 203-726-8
Source: EPA TSCA Inventory (July 2025 release) · ECHA CHEM — retrieved 2026-07-12
Regulatory restriction status
Tetrahydrofuran (THF) (CAS 109-99-9) appears on the regulatory list(s) below. This is public regulatory information about the substance — not a statement about any specific supplier’s material, and not a safety claim. Confirm the current status for your jurisdiction and intended use.
- California Proposition 65: listed for cancer, listed 17 Dec 2021. A California Proposition 65 warning applies (see the warning above).
Sources: ECHA Candidate List / Annex XIV / Annex XVII (echa.europa.eu); U.S. EPA TSCA; UN Stockholm Convention / EU POPs Regulation; California OEHHA Proposition 65 list. Retrieved 2026-07-13.
Frequently Asked Questions
What is tetrahydrofuran (THF) used for?
THF (CAS 109-99-9) is a strong aprotic cyclic-ether solvent used to dissolve high polymers, especially PVC, in printing inks, adhesives, lacquers, and coatings, as a reaction medium for Grignard and metal-hydride reactions, and as a chemical intermediate.
What is the difference between ACS grade and reagent grade?
ACS grade meets the purity specifications set by the American Chemical Society and is the standard high-purity grade for analytical and research work. Reagent grade also denotes high purity suitable for laboratory use; ACS reagent grade indicates the material meets ACS-defined limits for assay and impurities.
Where can I buy THF solvent?
RawSource supplies tetrahydrofuran in bulk industrial and reagent ACS grades to manufacturers and laboratories. Request a bulk quote with your target grade, packaging, and volume; CoA and SDS are available on request.
How does THF ship under DOT?
THF is assigned UN 2056 (TETRAHYDROFURAN), a flammable liquid. Confirm the packing group, packaging, and documentation against the current SDS before shipping.
What is the cost of bulk THF?
Bulk THF pricing depends on grade, packaging, and volume. Request a quote from RawSource with your target quantity for current pricing and lead time.
What is the REACH and TSCA regulatory status of Tetrahydrofuran (THF)?
Tetrahydrofuran (THF) (CAS 109-99-9) is subject to U.S. TSCA Inventory requirements; supplying it into the EU requires valid REACH registration ((EC) No 1907/2006). RawSource cannot verify a third-party supplier's registrations — buyers should require documented TSCA and REACH compliance for their jurisdiction and volume (EC 203-726-8).