Amines & Amides Available — Bulk Only

L-Proline

CAS 147-85-3 · Formula C5H9NO2 · MW 115.13 g/mol

A versatile amino-acid building block bridging fermentation media, food fortification, and fine-chemical synthesis. It is used as a component of microbiological culture media, as a flavoring agent and nutritional ingredient in food, and as a starting material in pharmaceutical synthesis.

Part of Amines & Amides
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HS Code
2922.49
At a Glance
Material Family
Amines & Amides
Record Type
Pure compound
Primary Role
Conditioning · Moisture Control
Solubility
162000 mg/L (at 25 °C)
Applications & Use Cases
  • Cell-culture media: nitrogen source and supplement in microbiological and fermentation media
  • Food & nutrition: flavoring agent and nutritional supplement ingredient
  • Pharmaceutical synthesis: starting material and intermediate for active-ingredient manufacture
  • Research reagent: laboratory biochemical and microbiological testing
  • Asymmetric catalysis: organocatalyst for chiral synthesis
Physical Properties
Melting Point
221 dec °C
Density
1.064 at 24 °C
Solubility
162000 mg/L (at 25 °C)
Safety & Handling
Full SDS available on request

A grade-specific Safety Data Sheet (SDS) — with the complete hazard classification, handling precautions, and transport information — is supplied with every shipment and available on request. Confirm all safety and regulatory details against the SDS for your specific grade.

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HS / Tariff Classification
Harmonized System (HS) Code — 6-digit international heading
2922 . 49
Chapter 29
Organic chemicals
Heading 29.22
Internationally harmonized (WCO HS)
Subheading 2922.49
6-digit international code — national tariff line adds further digits
Chemical Identity
CAS Number
147-85-3
Molecular Formula
C5H9NO2
Molecular Weight
115.13 g/mol
IUPAC Name
(2S)-pyrrolidine-2-carboxylic acid
PubChem CID
InChI Key
ONIBWKKTOPOVIA-BYPYZUCNSA-N
Synonyms & Trade Names
L-proline proline L-(-)-Proline (2S)-pyrrolidine-2-carboxylic acid (S)-Pyrrolidine-2-carboxylic acid (-)-Proline 2-pyrrolidinecarboxylic acid (-)-(S)-Proline (S)-2-Pyrrolidinecarboxylic acid prolina Prolinum (S)-Proline (-)-2-Pyrrolidinecarboxylic acid L-Prolin L-alpha-Pyrrolidinecarboxylic acid (S)-2-Carboxypyrrolidine Prolinum [Latin] FEMA No. 3319 2-Pyrrolidinecarboxylic acid, (S)-
Full Description

L-Proline (CAS 147-85-3) is a non-essential proteinogenic amino acid supplied as a crystalline powder. It is used as a component of microbiological culture media, as a flavoring agent and nutritional ingredient in food, and as a starting material in pharmaceutical synthesis. It also serves as a biochemical research reagent and an organocatalyst.

Frequently Asked Questions

What is L-Proline used for?

L-Proline (CAS 147-85-3) is a non-essential proteinogenic amino acid supplied as a crystalline powder. It is used as a component of microbiological culture media, as a flavoring agent and nutritional ingredient in food, as a starting material in pharmaceutical synthesis, and as an organocatalyst for asymmetric (chiral) synthesis.

What is the pKa of proline?

Proline has two ionizable groups: a carboxyl group with a pKa near 1.99 and the secondary-amine (imino) group with a pKa near 10.6, giving an isoelectric point around pH 6.3. Confirm exact figures against your lot specification and reference data.

Where does L-Proline come from?

Commercial L-proline is typically produced by microbial fermentation, yielding the single L-enantiomer as a crystalline powder. This material is supplied to USP specification with Kosher certification.

What is the CAS number, formula, and HS code?

CAS 147-85-3, formula C5H9NO2, HS 2922.49 (oxygen-function amino-compounds, other). Supplied USP-grade and Kosher-certified; lot-specific CoA and SDS are available on request.

What bulk packaging and order quantities are available?

It is distributed as a USP/Kosher-grade ingredient in bulk packaging for manufacturing and media applications. Submit your target volume and documentation needs through a bulk RFQ for current pricing, pack sizes, and lead time.

Disclaimer. Information on this page — including properties, identifiers, hazard, transport (DOT/UN) and tariff (HS) classifications, and applications — is provided for general reference and is compiled from authoritative public sources (e.g. PubChem/ECHA, 49 CFR 172.101, the Harmonized Tariff Schedule). Values are typical and are not a guaranteed specification; the Certificate of Analysis (CoA) for the lot purchased governs. Products are sold for industrial and professional use only. Nothing here is a medical, health, or efficacy claim or advice. Always consult the current Safety Data Sheet (SDS) before handling, storage, transport or disposal, and confirm regulatory status, classification and suitability for your application and jurisdiction. Hazard, transport and tariff classifications must be verified for your specific shipment. RawSource makes no warranty, express or implied, and assumes no liability for use of this information. Trademarks. Third-party trademarks and brand names are the property of their respective owners; any reference is nominative — used only to identify a comparable product — and does not imply affiliation with, sponsorship by, or endorsement by the trademark owner.