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Acetamide (Ethanamide)

CAS 60-35-5 · Formula C2H5NO · MW 59.07 g/mol

A simple organic amide used as a solvent, plasticizer, and intermediate in synthesis of pharmaceuticals, textiles, and specialty chemicals.

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HS Code
2924.19
At a Glance
Material Family
Acids & Salts
Record Type
Pure compound
Primary Role
Solvency · Synthesis Intermediate
Solubility
Very soluble (≥ 100 mg/mL at 22 °C)
Functional Roles
Industries Served
Applications & Use Cases
  • Solvent: Dissolves many organic and inorganic compounds in the molten state.
  • Plasticizer: Softener for paper, leather, textiles, and certain plastics.
  • Wetting/penetrating agent: Hygroscopic processing aid.
  • Intermediate: Reactant and stabilizer in organic synthesis.
Physical Properties
Melting Point
82 °C
Boiling Point
221 °C at 760 mmHg
Density
1.159 at 20 °C
Solubility
Very soluble (≥ 100 mg/mL at 22 °C)
Vapor Pressure
1 mmHg at 65 °C
Safety & Handling
Full SDS available on request

A grade-specific Safety Data Sheet (SDS) — with the complete hazard classification, handling precautions, and transport information — is supplied with every shipment and available on request. Confirm all safety and regulatory details against the SDS for your specific grade.

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HS / Tariff Classification
Harmonized System (HS) Code — 6-digit international heading
2924 . 19
Chapter 29
Organic chemicals
Heading 29.24
Internationally harmonized (WCO HS)
Subheading 2924.19
6-digit international code — national tariff line adds further digits
Chemical Identity
CAS Number
60-35-5
Molecular Formula
C2H5NO
Molecular Weight
59.07 g/mol
IUPAC Name
acetamide
PubChem CID
InChI Key
DLFVBJFMPXGRIB-UHFFFAOYSA-N
Synonyms & Trade Names
acetamide Ethanamide Acetic acid amide Methanecarboxamide Acetimidic acid Ethanimidic acid Amid kyseliny octove NCI-C02108 CH3CONH2 AI3-02060 FEMA NO. 4251 acetamido
Full Description

⚠ WARNING: This product can expose you to Acetamide, which is known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.

Acetamide (CAS 60-35-5) is the simplest acyclic amide. It is used as a solvent, plasticizer, stabilizer, and wetting/penetrating agent, and as a humectant and intermediate in organic synthesis. Molten acetamide is an effective solvent for many organic and inorganic compounds.

Regulatory & registration requirements

  • TSCA (US):
  • REACH (EU):
  • EC number: 200-473-5

Source: EPA TSCA Inventory (July 2025 release) · ECHA CHEM — retrieved 2026-07-12

Regulatory restriction status

Acetamide (Ethanamide) (CAS 60-35-5) appears on the regulatory list(s) below. This is public regulatory information about the substance — not a statement about any specific supplier’s material, and not a safety claim. Confirm the current status for your jurisdiction and intended use.

  • California Proposition 65: listed for cancer, listed 1 Jan 1990. A California Proposition 65 warning applies (see the warning above).

Sources: ECHA Candidate List / Annex XIV / Annex XVII (echa.europa.eu); U.S. EPA TSCA; UN Stockholm Convention / EU POPs Regulation; California OEHHA Proposition 65 list. Retrieved 2026-07-13.

Frequently Asked Questions

What is acetamide commonly used for?

Acetamide (CAS 60-35-5) is the simplest acyclic amide. It is used as a solvent, plasticizer, stabilizer, and wetting/penetrating agent, as a humectant, and as an intermediate in organic synthesis. In its molten state it is an effective solvent for many organic and inorganic compounds.

Is CH3CONH2 the same as ethanamide?

Yes. CH3CONH2 is acetamide, whose IUPAC name is ethanamide; the two names refer to the identical compound, CAS 60-35-5. "Acetamide" is the common name and "ethanamide" is the systematic name.

What is ethanamide (acetamide) used for in industry?

As ethanamide it serves the same roles: a molten solvent for organic and inorganic compounds, a plasticizer/softener for paper, leather, textiles, and certain plastics, a hygroscopic wetting and penetrating agent, and a reactant or stabilizer in organic synthesis.

What is the CAS number and molecular formula of acetamide?

Acetamide has CAS number 60-35-5 and molecular formula C2H5NO, classified in the Acids & Salts family. Its HS classification is 2924.19 (acyclic amides and derivatives, other).

Where do I find handling data, and how is bulk acetamide supplied?

Handling, GHS classification, and storage guidance are in the product Safety Data Sheet, supplied by RawSource with every order. RawSource ships reagent acetamide crystal with CoA and SDS per lot, packaged and priced per order; submit a bulk RFQ for a current quote and lead time.

What is the REACH and TSCA regulatory status of Acetamide (Ethanamide)?

Acetamide (Ethanamide) (CAS 60-35-5) is subject to U.S. TSCA Inventory requirements; supplying it into the EU requires valid REACH registration ((EC) No 1907/2006). RawSource cannot verify a third-party supplier's registrations — buyers should require documented TSCA and REACH compliance for their jurisdiction and volume (EC 200-473-5).

Disclaimer. Information on this page — including properties, identifiers, hazard, transport (DOT/UN) and tariff (HS) classifications, and applications — is provided for general reference and is compiled from authoritative public sources (e.g. PubChem/ECHA, 49 CFR 172.101, the Harmonized Tariff Schedule). Values are typical and are not a guaranteed specification; the Certificate of Analysis (CoA) for the lot purchased governs. Products are sold for industrial and professional use only. Nothing here is a medical, health, or efficacy claim or advice. Always consult the current Safety Data Sheet (SDS) before handling, storage, transport or disposal, and confirm regulatory status, classification and suitability for your application and jurisdiction. Hazard, transport and tariff classifications must be verified for your specific shipment. RawSource makes no warranty, express or implied, and assumes no liability for use of this information. Trademarks. Third-party trademarks and brand names are the property of their respective owners; any reference is nominative — used only to identify a comparable product — and does not imply affiliation with, sponsorship by, or endorsement by the trademark owner.