Hydroxypropyl Tetrahydropyrantriol

Hydroxypropyl tetrahydropyrantriol (CAS 439685-79-7) is a C-glycoside cosmetic active — a hydroxypropyl-substituted tetrahydropyran triol derived from the natural sugar xylose. It is the molecule commercialized in personal care under the trade name Pro-Xylane, and it is supplied to formulators as a water-soluble specialty active for anti-aging and mature-skin systems. For a personal-care brand, its value is a sugar-based active with a stable C-glycosidic bond that resists enzymatic breakdown and slots cleanly into the water phase of a formula.

Applications and benefits in formulation

This active is positioned for the premium end of skin care, where formulators want a sugar-derived molecule with a documented mechanism story rather than a generic humectant. The notes below are formulation guidance for product developers — not consumer efficacy promises.

Anti-aging and mature-skin care

In cosmetic literature the molecule is studied as a stimulant of glycosaminoglycan (GAG) and proteoglycan synthesis in the dermal matrix, the components associated with skin firmness and elasticity. That mechanism is why it anchors anti-aging serums, firming creams, and mature-skin ranges. Frame it on your label as a structural-support active rather than a treatment: the supporting data is cosmetic, not medical, so claims must stay general and non-therapeutic.

Hydration and skin-barrier systems

As a polyol carrying three hydroxyl groups plus a pendant hydroxypropyl chain, it is highly hydrophilic and interacts readily with water — useful in hydration-focused and barrier-support formulas. It pairs naturally with hyaluronic acid, glycerin, and niacinamide in moisturizing systems, contributing structure-and-moisture positioning without the tackiness of a high-glycerin load.

Eye, serum, and cream formats

Because it is delivered as an aqueous solution and is water-soluble, it formulates easily across leave-on formats: lightweight eye treatments, anti-aging serums, day and night creams, and emulsions. Add it to the water phase. The active is typically introduced cold or in a cool-down step rather than held at high process temperatures, which keeps it compatible with heat-sensitive co-actives in the same batch.

Compatibility and use levels

Hydroxypropyl tetrahydropyrantriol is water-soluble and is incorporated in the aqueous phase; published formulation guidance places typical leave-on use in the low single-digit percent range of the supplied solution and a working pH window in the mildly acidic to neutral range. Treat those figures as a starting point only — confirm the active percentage, recommended use level, and pH and temperature limits against the supplier specification and your own stability work before locking a formula.

Forms and grade

The material is supplied as an aqueous (water-based) solution rather than a dry powder; commercial grades are commonly offered at a defined active percentage in water (around 30% active is a widely used presentation), typically as a clear to pale-yellow liquid. Active content, exact INCI declaration, and appearance can vary by source, so confirm the percent-active basis on the Certificate of Analysis for the lot you order — your use level must be calculated against that figure, not the neat molecule.

Handling

Store and handle per the Safety Data Sheet supplied with each lot; the SDS governs storage, handling, and disposal for the specific grade you receive. As an aqueous active it is generally handled as a water-phase cosmetic raw material, but always confirm the current SDS for the grade on hand before processing.

Bulk sourcing from RawSource

RawSource sources hydroxypropyl tetrahydropyrantriol (Pro-Xylane) in bulk for personal-care manufacturers and contract formulators — from sample quantities for bench work up to drum, tote, and IBC volumes for production. We work on an RFQ basis: send your CAS or INCI, target active percentage, and volume, and we will return pricing, MOQ, packaging, and lead time. Request a quote to start sourcing.